This is a WWW server for multiple alignment of protein and
nucleic acid sequences using DIALIGN with user-defined anchor points.
Alignments can be created either fully automatically or by using a list
of user-defined constraints.
By specifying such anchor points, the user can force the program to
align selected segments of the sequences to each other. The remaining parts
of the sequences are then
aligned automatically, respecting the constraints imposed by
the selected anchor points.
An anchor point consists of a pair of
equal-length segments from different input sequences that are to
be aligned. An
explains all features of the anchored alignment procedure.
Our method is described in
Please note that the present server is designed for protein and
nucleotide sequences of moderate length (up to a few kb). For alignment
of larger genomic sequences, we offer a
WWW server using the integrated CHAOS/DIALIGN software described by
et al. (2004), Nucleic Acids Res. 32, W41-W44.
The program source code is available for